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Cilgavimab serum pharmacokinetics

Explore serum cilgavimab exposure with fixed patient covariates using the publication’s main coefficient profile. Alternative coefficient estimates and population variability are outside this reference model.

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MODEL IN MOTION 18 sec

How do gluteal and thigh administration change cilgavimab exposure?

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Cilgavimab 300 mg IM fixed covariate reference

Cilgavimab fixed-covariate main Table 1 reference with explicit per-component administration.

0–1,000 day

Scenario details

Cilgavimab 300 mg IM fixed covariate reference

Cilgavimab fixed-covariate main Table 1 reference with explicit per-component administration.

Readouts

Central conc · ug/mL
Central conc over the selected simulation window.
Exposure (AUC) · ug*day/mL
Exposure (AUC) over the selected simulation window.
Empirical input accounted · mg
Empirical input accounted over the selected simulation window.

Study purpose

  • How do the model's key biological readouts change under cilgavimab 300 mg im fixed covariate reference?

Assumptions

  • Fixed component serum PK with main Table 1 coefficient values; no original cohort fit or population reproduction.
  • Each history gives a per-component 300 mg dose, the corresponding part of a 600 mg 1:1 AZD7442 combination.
  • One-hour IV duration is an explicit research assumption. All administration targets are explicit.
  • Covariates stay fixed within each history; categorical associations do not imply causal mechanisms.
  • The peripheral pool is apparent. AUC and elapsed time are nonfeedback observers.
  • The component ledger weights the nominal IM depot by FIM; separately fitted component and total-model curves are not constrained to sum.
  • No arbitrary control ranges, sampling, likelihood, fitting, viral dynamics, efficacy or individual treatment advice is provided.

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Simulation time
day
day
1000 → 168

Time between reported samples.

day

1 change · Variation 1

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Biology

Cilgavimab serum PK under fixed covariates using the named main Table 1 coefficient profile.

Cilgavimab serum PK under fixed covariates using the named main Table 1 coefficient profile.

Model details

21 parameters · 5 states · 5 equations · 18 derived outputs

Classification & API access
Therapeutic
Cilgavimab
Modality
Monoclonal antibody
Target
SARS-CoV-2 Spike RBD
Disease / scope
COVID-19 exposure study
ParameterDefaultUnitDescription
Beta clearance diabetesbeta_cl_diabetes0.149—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Beta fim thighbeta_fim_thigh0.414—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Beta absorption rate age OVER65beta_ka_age_over65-0.392—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Beta absorption rate bmi GE30beta_ka_bmi_ge30-0.188—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Beta absorption rate diabetesbeta_ka_diabetes-0.27—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Beta absorption rate malebeta_ka_male0.57—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Beta central distribution volume blackbeta_vc_black-0.26—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Body weightbody_weight_kg80.6kgFixed Table1 component coefficient or selected covariate for this conditional reference.
Systemic clearancecl_l_day0.0516L/dayFixed Table1 component coefficient or selected covariate for this conditional reference.
Intramuscular bioavailability fractionfim_fraction0.658—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Has diabeteshas_diabetes0—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Is age OVER65is_age_over650—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Is black raceis_black_race0—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Is bmi GE30is_bmi_ge300—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Is maleis_male1—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Is thigh injectionis_thigh_injection0—Fixed Table1 component coefficient or selected covariate for this conditional reference.
Absorption rate constantka_1_day0.1191/dayFixed Table1 component coefficient or selected covariate for this conditional reference.
Intercompartmental clearanceq_l_day0.485L/dayFixed Table1 component coefficient or selected covariate for this conditional reference.
Reference weightreference_weight_kg70kgFixed Table1 component coefficient or selected covariate for this conditional reference.
Central distribution volumevc_l3.52LFixed Table1 component coefficient or selected covariate for this conditional reference.
Peripheral distribution volumevp_l1.82LFixed Table1 component coefficient or selected covariate for this conditional reference.

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