FoldCraft
Redesign a binder against a fixed protein target.
Results
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Method & evidence
Design binders from FoldCraft templates, then compare sequences, complexes, and stage scores.
Interpreting results
- FoldCraft scores are model-derived design evidence, not measured affinity, stability, expression, or function.
- Compare candidates only within runs using identical templates, chains, hotspots, models, and stage settings.
- Inspect interface geometry and sequence liabilities before advancing a design.
References
Input requirements & outputs
Input checks
- One binder PDB and one target PDB
- Explicit binder and target chains with valid target hotspot residue ranges
- One to four trajectories in the released batch, with up to four ProteinMPNN samples each
Expected results
- Designed sequences and ranked metrics — Compare trajectory, sequence, confidence, loss, and interface evidence in one table.
- Predicted binder–target structures — Inspect each PDB in the 3D viewer.
- Run settings — Templates, hotspots, models, and design settings.
