RFdiffusion3
Generate all-atom structures under molecular constraints.
Results
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Method & evidence
Design protein or small-molecule binders and enzyme scaffolds from supplied 3D structures.
Scope & limitations
- The released operation is RFdiffusion3; nucleic-acid RFdiffusion3NA remains outside this capability.
Interpreting results
- Generated structures are design hypotheses, not affinity, catalytic-rate, or functional measurements.
- Compare candidates within a single mode and parameter profile before applying structural ranking.
- Ligand identity checks establish that the requested component is represented; experimental validation remains required.
References
Input requirements & outputs
Input checks
- One PDB file
- Mode-specific target segments and ligand identity supplied when required
- 1–4 generated structures with an explicit seed
Expected results
- Generated all-atom structures — Compare designs by mode, seed, and sequence.
- Interactive molecular artifacts — Inspect structures in 3D or download the PDB files.
- Conditioning and ligand evidence — Review target, ligand, active-site, and result-identity checks for the chosen mode.
